Name of the Journal Journal of Ayurveda Academia (JAA) ISSN (Online) 3107-9687 Started from January 2025 A.D. Journal URL www.ayuacademia.com Discipline/Domain Medical Sciences Availability Online Frequency Language Bi-annual (June & December) English Review process Plagiarism policy Double blinded peer review As per UGC guidelines Subscription: Open access JAA Vision (Future) Build a reliable and relevant research repository of Ayurveda Medical Sciences JAA Mission (Present) Building a global nexus of researchers, faculty, professionals, and stakeholders of Ayurveda for the globalization of authentic Ayurveda Medical Sciences. JAA Objectives (i) Promote research initiatives in Ayurveda Medical Sciences (ii) Publish and publicize research conducted in Ayurveda Medical Sciences (iii) Encourage application of research findings Editor Editorial office Prof. Sushanta Kumar Sahoo Bareilly, Uttar Pradesh, India 243006 Publisher © Publisher’s office Contact Email AYURVEDA PANDIT (Publication House) Near J.N.B. School, Village Post Office Paprola, Tehsil Baijnath Kangra, Himachal Pradesh 176115 Mobile: + 91-6307709145 ayuacademia@gmail.com
A Meta-Analytical Study of Shatavari (Asparagus racemosus Willd) References in Classical Ayurvedic Samhitas
An extensive meta-analysis was conducted to systematically compile and interpret references to Shatavari (Asparagus racemosus Willd) across the foundational Ayurvedic treatises—Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Kashyap Samhita, Bhela Samhita, Harita Samhita, and Sharangadhara Samhita. The objective was to elucidate the formulation , therapeutic roles, and route of administration attributed to this revered plant, traditionally known as the “Queen of Herbs.” The analysis integrates classical knowledge with interpretations from textual research, highlighting Shatavari’s continuity of use from antiquity to contemporary Ayurvedic practice in various forms.
Shatavari, Asparagus racemosus, Ayurveda, Charaka Samhita, Sushruta Samhita, Rasayana, Meta-analysis
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Lekhaniya Mahakashaya in the Management of Lifestyle Disorders: A Critical Review
Background: Lifestyle disorders including obesity, dyslipidemia, and metabolic syndrome represent a growing global health challenge. Lekhaniya Mahakashaya, a classical Ayurvedic formulation comprising ten medicinal herbs, has been traditionally employed for managing disorders of fat metabolism (Medodushti) through its unique Lekhana Karma (scraping action). Objective: This critical review examines the concept of Lekhana Karma, evaluates the pharmacological profiles of the ten constituent drugs (Musta, Kushtha, Haridra, Daruharidra, Vacha, Ativisha, Katurohini, Chitraka, Chirabilva, and Haimavati), and synthesizes clinical evidence for their efficacy in obesity, dyslipidemia, and metabolic syndrome. Methods: A comprehensive review of classical Ayurvedic texts, contemporary clinical trials, and pharmacological studies was conducted to evaluate the therapeutic potential of Lekhaniya Mahakashaya in lifestyle disorders. Results: The constituent drugs predominantly possess Tikta (bitter), Katu (pungent), and Kashaya (astringent) Rasa; Laghu (light), Ruksha (dry), and Tikshna (sharp) Guna; Ushna Virya (hot potency); and Katu Vipaka (pungent post-digestive effect). Clinical studies demonstrate significant improvements in body mass index, lipid profiles, oxidative stress markers, and metabolic parameters. The formulation exhibits Medohara (lipolytic), Deepana (appetizer), Pachana (digestive), and Srotoshodhana (channel-cleansing) properties. Conclusion: Lekhaniya Mahakashaya represents a promising therapeutic approach for lifestyle disorders through its multi-targeted pharmacological actions. However, larger randomized controlled trials with standardized formulations are needed to establish definitive clinical efficacy and safety profiles.
Lekhaniya Mahakashaya, Lekhana Karma, Obesity, Dyslipidemia, Metabolic Syndrome, Medoroga, Lifestyle Disorders
Copyright (c) 2026 Journal of Ayurveda Academia https://creativecommons.org/licenses/by-nc-sa/4.0
A Case Study on Ayurvedic Management of Papulo-Pustular Skin Lesions in a Pediatric Patient: An Integrative Approach Following Virechana Therapy
This case study Describes the Ayurveda management of a chronic dermatological condition in a nine-year-old male child who presented with pustular and papular lesions over the groin and shoulder regions. The lesions were accompanied by severe itching and serous discharge and had persisted for more than one month despite prior allopathic treatment. An individualized and holistic Ayurveda treatment plan was designed based on classical principles to address both local symptoms and systemic imbalance. The therapeutic approach began with Deepana and Pachana therapies to improve Agni and eliminate Ama. This was followed by Snehapana and Virechana to expel aggravated Pitta and Kapha Doshas from the body. External treatments, including Abhyanga with medicated oils, were used to support skin healing and reduce inflammation. After the detoxification phase, Samsarjana Krama was implemented to gradually restore Agni and metabolic balance. Shamana Chikitsa with appropriate herbal formulations was administered to control symptoms and prevent recurrence, while Rasayana therapy was included to enhance immunity and promote tissue regeneration. The child showed marked clinical improvement, with significant reduction in itching, discharge, and lesion size, ultimately achieving complete resolution. No recurrence was noted during follow-up, highlighting the potential of systematic Ayurveda management in pediatric dermatology cases.
Kustha, Papulo-pustular lesion, Panchakarma, Ayurveda
Clinical Case Studies: The Living Evidence of Ayurveda
Dear Readers and Esteemed Colleagues, Following the encouraging response to the inaugural issue of the Journal of Ayurveda Academia (JAA), it gives me immense pleasure to present Volume 1, Issue II of our journal. This issue represents a natural progression in our journey to provide a credible, peer‑reviewed platform for the dissemination of scholarly work in Ayurveda and allied sciences. While the first issue highlighted experimental, review, and conceptual research, the present issue distinctly emphasizes clinical case studies, reflecting the living, practice‑oriented nature of Ayurveda. Case studies form the backbone of clinical Ayurveda, where individualized diagnosis (Rogi–Roga Pariksha), personalized treatment protocols, and holistic outcomes are documented in real‑world settings. By curating a substantial number of well‑structured clinical case reports, this issue strengthens the bridge between classical principles and contemporary clinical practice.
Case Study, Evidence Based Ayurveda, JAA
Copyright (c) 2025 Journal of Ayurveda Academia https://creativecommons.org/licenses/by-nc-sa/4.0
Effective Management of Artavakshaya w.s.r to Oligo-hypomenorrhea through Ayurveda Regimen: A Case Study
Introduction Menstruation is the act of nature and important part of woman’s life that occurs as a regular rhythmic period and remains as a normal physiological The journey from menarche to menopause involves continuous cyclical changes, and any deviation in the normal quantity or duration of menstrual flow—with or without associated pain—can be linked to conditions such as Vātaja raja-duṣṭi, Kṣīṇārtava, or Ārtava-kṣaya. In these situations, Vāta and Kapha cause mārga-āvaraṇa, which obstructs the natural passage of Ārtava and results in its depletion. Since Ārtava possesses an agneya quality and is primarily governed by Pitta dosha, the specific causative factors for Ārtava-kṣaya can be understood as those that aggravate Vāta-Kapha or lead to Pitta depletion. Methodology A 26-year-old woman visited the OPD at PLRD Hospital, Khurja, on 27/10/2024 with the primary complaints of scanty and delayed menstrual cycles. For the past three years, her periods had been occurring every 40–45 days, with menstrual bleeding lasting only 2–3 days. She also reported moderate dysmenorrhea, which was evaluated using the Visual Analogue Scale. The patient underwent treatment with Laśuna Kalpa for two successive cycles, considering its agneya, srotoshodhaka, kapha-vāta–śāmaka, pitta-vardhaka, and vāta-anulomaka actions. After completing the therapy, she was observed for one additional cycle without medication. Result and Conclusion The patient had regular menstruation with normal duration and interval, with an adequate amount of menstrual flow and the intensity of pain was reduced effectively from moderate to mild. Even after cessation of medicine, she got her menstruation in 30 days with a normal amount of flow.
Artavakshaya , Artavadushti,Oligo- hypomenorrhea, Agneya
Ayurvedic Approach in the Management of Kaphaja-abhishyanda with Nasanaha (Vernal Kerato Conjunctivitis with Inferior Turbinate Hypertrophy): A Case Study
Introduction: Abhishyanda are of four types and Kaphaja Abhishyanda is one among them. The sign and symptoms of Kaphaja Abhishyanda is like the sign and symptom of Vernal Kerato-Conjunctivitis (VKC). In this condition, the antihistamines and steroids are the drug of choice. In Ayurveda, these conditions are treated with Lekhana and Kapha-Pitta Shamaka Upakrama in the form of Netrasheka, Aschyotana, Anjana, Nashya, Raktamokshyana and Shamana Aushadhi. Patient information: A 4.6-year-old male child having intense eye itching, photophobia, dusky eyes, watering of eyes came to our OPD with his parents for Ayurvedic treatment. The patient had bilateral inferior turbinate hypertrophy, and he was a case of mild Deviated Nasal Septum (DNS), he also had dried with itchy skin. Material and Methods: Considering the case as Kaphaja Abhishyanda, we managed the case with Netra Kriyakalpa (~Topical Ayurvedic ocular therapy), Pratimarsha Nashya, and Kapha-Pitta Shamaka Aushadhi (~Conservative treatment). Results: After seven days of treatment, the eye became clear. The photophobia, congestion, size and number of Trantas spot reduced. The gelatinous ring faded. Grossly speaking there is improvement in the patient’s eye. The dryness, itching of skin and nasal congestion was also reduced. Conclusion: The sign and symptoms of the VKC eyes are effectively treated with Netra Kriyakalpa and Shamana Aushadhi. The Netrasheka, Anjana, Nashya, and Kapha-Pitta Shamaka treatment can be an effective alternative of the antihistamine and steroidal eye drops in VKC.
Case report on Kaphaja Abhishyanda, Ayurvedic treatment of VKC, Kaphaja Abhishyanda, Yashtimadhu Ksheerapaka Netrasheka, Netrasheka.
Management of Allergic Rhinitis (Vata-Kaphaja Pratishyaya) through Ayurvedic Therapeutics: A Case Study
Introduction: Allergic rhinitis is a chronic inflammatory disorder of the nasal mucosa presenting with recurrent sneezing, watery nasal discharge, nasal obstruction, and itching, leading to impaired quality of life. The clinical features closely resemble Pratishyaya described in Ayurveda, particularly of Vāta-Kaphaja predominance. Conventional management often provides temporary symptomatic relief with frequent recurrence. Objective: To evaluate the effectiveness of Nasya Karma along with Śamana Cikitsā in the management of allergic rhinitis (Vāta-Kaphaja Pratishyaya). Method: A diagnosed case of allergic rhinitis was treated with Mārśa Nasya using Anu Taila for 7 consecutive days following standard Pūrva and Paścāt Karma. Internal Śamana medications including Sitopalādi Cūrṇa and Haridrā Khaṇḍa were administered for 30 days. Assessment was done based on subjective improvement in sneezing, nasal discharge, nasal obstruction, and itching. Result: The patient showed marked reduction in sneezing frequency, nasal discharge, obstruction, and itching, along with improvement in breathing and general well-being. No adverse effects were observed, and sustained relief was noted during follow-up. Conclusion: Nasya Karma combined with appropriate Śamana Cikitsā was found to be effective and safe in the management of allergic rhinitis. This approach addresses the underlying Doṣa imbalance and may help in preventing recurrence.
Pratishyaya, Allergic rhinitis, Nasya, Ayurveda, Vata-Kapha
Ayurvedic Perspective and Management of Shingles (Herpes Zoster) in an Elderly Patient with Dorsal Lesions: A Case Report
Background: Herpes zoster, also known as shingles, is caused by reactivation of the varicella-zoster virus (VZV) and presents as painful, vesicular eruptions along dermatomes, primarily affecting the elderly. In Ayurveda, it is comparable to Visarpa (a rapidly spreading skin disorder), a Tridoshaja (involving all three doshas) condition affecting Twak (skin), Rakta (blood), Mamsa (muscle tissue), Lasika (lymph), and Sweda (sweat). This case report explores an Ayurvedic approach to herpes zoster using classical formulations. Patient Information: A 60-year-old female presented with painful vesicular eruptions, burning sensation, and discharge on the right posterolateral back for one month. She had previously been treated with antivirals (Acyclovir, Famciclovir) with minimal relief. Intervention: A Shamana (palliative) line of treatment was undertaken. The patient was administered Arogyavardhini Vati (an herbal tablet for detoxification and liver function) 500 mg TDS, Panchnimba Churna (five-herb neem-based powder) 3 g BD, and Jatyadi Taila (wound-healing herbal oil) applied locally for 21–30 days. Dietary and lifestyle modifications (Pathya-Apathya) were also advised. Results: Within two weeks, significant symptomatic relief was noted. Vesicles healed, pain and discharge subsided, and no new eruptions appeared. No postherpetic neuralgia or scarring was observed during follow-up. Conclusion: This case demonstrates effective management of herpes zoster through Ayurvedic interventions focused on Pitta-Rakta Shamana (balancing the pitta dosha and purifying the blood) and Vrana Ropana (wound healing). The selected drugs facilitated rapid healing and prevented complications. Larger-scale clinical trials are warranted to establish the efficacy of Ayurvedic protocols in viral dermatoses.
Herpes Zoster, Visarpa, Tridosha, Raktashodhana (blood purification), Jatyadi Taila
A Randomised Controlled Clinical Trial to Evaluate the Effect of Jatamansi and Ashwagandha Moola Churna in the Management of Anidra w.s.r to Insomnia
ABSTRACT Background: Insomnia is one of the burning problems not only in India but also all over the world. According to the statistics, 20% - 40% of adults encounter insomnia-related problems within a year. Especially 15 to 55 years old are more affected. Long-term uses of certain classes of sedatives such as benzodiazepines and newer non-benzodiazepine drugs cause physical dependence, with several side effects such as daytime fatigue. Objectives: To evaluate the clinical efficacy of Jatamansi (Nardostachys jatamansi DC.) and Ashwagandha (Withania somnifera Dunal) moola churna in anidra (Insomnia). Materials and Methods: A randomized, open-label, interventional clinical trial was conducted with 60 patients (30 in each group). Group A received Jatamansi moola churna (JMC) and Group B received Ashwagandha moola churna (AMC), both in capsule form for internal use. Treatment was administered once daily at night for 30 days. Improvement was assessed based on Ayurvedic subjective parameters: Angmarda, Shirogaurva. Jrimbha, Jadyata, Apakti, Bhrama, Glani, Tandra, Vataj roga and modern parameters Pittsburgh Sleep Quality Index (PSQI). Results: Both Groups showed statistically significant improvement (p<0.001). Jatamansi moola churna was slightly more effective, particularly in reducing Angmarda, Shirogaurva. Jrimbha, Jadyata, Apakti, Glani, Tandra, Sleep duration, Sleep disturbance, daytime dysfunction Ashwagandha moola churna was more effective in Bhrama vataj roga, sleep latency. Conclusion: The study concludes that both drugs Jatamansi and Ashwagandha have effective role in subsiding symptoms associated with Anindra (Primary insomnia). However, Jatamansi was found to be more effective than Ashwagandha upon comparison.
Anidra, Insomnia, Jatamansi, Ashwagandha, Pittsburgh Sleep Quality Index, Churna
Unveiling the Multifaceted Benefits of Dhanvantaram Taila: Insights from Ashtanga Hridayam
ABSTRACT Background: Ayurveda offers a variety of herbal remedies aimed at naturally preventing diseases and promoting health. One of the significant Ayurvedic formulations is "taila" (oil), which is used both topically and internally for health maintenance and treatment. Objective: To explore the therapeutic uses and properties of Dhanvantaram Taila, particularly its effectiveness in managing Vata Vyadhi and associated ailments caused by Vata dosha vitiation. Methods: A comprehensive literature review was conducted using classical Ayurvedic texts, including Ashtanga Hridayam Shareera Sthana and Dravyaguna Vigyan. The review focused on the ingredients, properties, and indications of Dhanvantaram Taila. Results: Most of the ingredients in Dhanvantaram Taila exhibit balya (strengthening) and Vata shamaka (Vata-pacifying) properties. The formulation predominantly contains ingredients with madhura rasa (sweet taste), which are beneficial in the treatment of Vata Vyadhi. The indications of Dhanvantaram Taila include Vata Roga, Sutika Roga (postpartum disorders), Bala Roga (pediatric disorders), Marma Hata (injuries to vital points), Asthi Hata (bone injuries), Ksheena Purusha (debilitated individuals), Jwara (fever), Gulma (abdominal lumps), and Graha Roga (psychological disorders). Conclusion: Dhanvantaram Taila is a multifaceted Ayurvedic formulation with extensive applications in managing conditions associated with Vata dosha imBalance. Its therapeutic efficacy is rooted in its carefully chosen ingredients, as detailed in classical Ayurvedic texts.
Efficacy of Ayurvedic Interventions in Managing Kroshtuksheersha: A Case Study
ABSTRACT Background: Movement is essential for daily functioning, and any restriction can cause significant discomfort and affect quality of life. In Ayurveda, disorders that involve impaired movement are primarily associated with Vata dosha and classified under Vatavyadhi. Kroshtuksheersha, as described by Acharya Sushruta, is one such Vatavyadhi, presenting with knee joint swelling, redness, and pain due to the combined predominance of Vata and Rakta doshas. This condition is uncommon in modern clinical practice. Objective: To evaluate the effectiveness of an Ayurvedic therapeutic regimen in the management of Kroshtuksheersha and its role in alleviating associated symptoms. Methods: An 18-year-old male with symptoms of knee swelling, redness, pain, and restricted mobility was diagnosed with Kroshtuksheersha. The treatment plan was designed to balance Vata dosha while preventing aggravation of Pitta and Rakta doshas. The therapeutic protocol involved the use of Aampachak drugs to eliminate Ama, Vatashamak and Raktashodhak medicines to pacify Vata and purify Rakta, followed by Janubasti therapy once inflammatory signs subsided to ensure complete pacification of Vata dosha. Outcomes were assessed using knee circumference, range of motion, pain level, and tenderness grading. Results & Conclusion: Over a three-month period, the patient demonstrated significant improvement, with noticeable reduction in swelling, redness, pain, and mobility restrictions. These findings suggest that Ayurvedic treatment can be highly effective in managing Kroshtuksheersha through a personalized approach targeting underlying dosha imbalances. Larger clinical studies are warranted to confirm these results and establish standardized treatment protocols.
Minimally Invasive Management of Pilonidal Sinus Using Kshara Sutra: A Clinical Case Study
ABSTRACT Background: Nadi Vrana, described in Ayurveda, refers to an ulcer with a tubular extension. Among its five types, Shalyaja Nadi Vrana is comparable to pilonidal sinus, characterized by a tract in the natal cleft region often caused by ingrown hairs (Shalya). Conventional treatments such as wide excision and reconstructive surgical techniques are associated with a high recurrence rate. The Ayurvedic approach using Kshara Sutra therapy offers a minimally invasive alternative with promising outcomes. Aim: To evaluate the clinical efficacy of Guggulu Nimba Kshara Sutra in the management of pilonidal sinus (Shalyaja Nadi Vrana). Case Presentation: A 28-year-old male patient presented with a painful swelling and discharge in the natal cleft region, diagnosed as pilonidal sinus. The patient was treated using Guggulu Nimba Kshara Sutra, a medicated thread prepared with Ayurvedic herbal formulations. The therapy involved gradual excision of the sinus tract through periodic tightening of the thread, promoting healing. Outcome: Complete excision of the tract was achieved within a span of six weeks with minimal scarring. The patient experienced significant symptom relief, no recurrence during follow-up, and resumed daily activities without discomfort. Conclusion: This case highlights the efficacy of Guggulu Nimba Kshara Sutra in managing pilonidal sinus, offering a cost-effective, minimally invasive treatment option with reduced recurrence rates and faster recovery compared to conventional methods.
Pramana Sharir Meets Contemporary Anthropometry: Correlation between Jangha Length and Height
ABSTRACT Background: Human stature estimation is a crucial component of anthropometry and forensic sciences, widely used in personal identification, ergonomics, and clinical evaluations. Ayurveda, a traditional holistic medical science, emphasizes body measurements under Pramāṇa Śārīra, focusing on individual constitution and symmetry. Objective: To integrate Ayurvedic concepts with modern scientific methods and investigate the correlation between tibial length (Jaṅghā) and total height in healthy individuals. Methods: A cross-sectional study was conducted on 100 healthy adults (50 males and 50 females) at a tertiary Ayurvedic institution in Uttar Pradesh, India. Tibial length was measured using standard anthropometric techniques, and total stature was recorded using a stadiometer. Statistical analyses, including linear regression, were performed to derive gender-specific predictive equations for stature estimation. Results: A significant positive correlation was observed between Jaṅghā length and stature, with correlation coefficients of 0.926 for males and 0.948 for females. Gender-specific regression equations were developed, showing minimal standard errors (±2.943 cm for males and ±1.974 cm for females). These results corroborate the reliability of tibial length as a predictor of stature and align with Ayurvedic principles of proportional body measurements. Conclusion: This study successfully bridges Ayurvedic principles with modern anthropometry, offering a reliable framework for applications in forensic medicine, public health, and ergonomic design. Further research should aim to standardize Ayurvedic units like Aṅgula and consider diverse demographic factors to improve the applicability of these findings.
Kshara Pratisarana in Arsha (II Degree Haemorrhoids): A Classical and Clinical Case Study
ABSTRACT Introduction: Arsha, commonly known as haemorrhoids, is a prevalent condition characterized by swollen blood vessels in the anal and rectal regions, leading to symptoms such as bleeding, pain, mucous discharge, and discomfort. Contributing factors include chronic constipation, prolonged sitting, straining during bowel movements, genetic predisposition, and unhealthy lifestyle choices like a sedentary routine and a low-fiber diet. Objective: To demonstrate the efficacy of Kshara karma in the management of Arsha through a case report. Methods: A 30-year-old male patient presented at the Shalya OPD, Corporate College of Ayurvedic Science, Bhopal, with symptoms of a protruding mass during defecation, rectal bleeding, and mucous discharge. The patient was treated with Kshara karma using Apamarga Kshara, an alkaline preparation. Treatment outcomes were monitored over 15 days. Results: Within 7 days of treatment, the pile mass, rectal bleeding, and mucous discharge resolved. The patient reported being symptom-free by the 15th day. Conclusion: Kshara karma proved to be an effective treatment for managing Arsha, providing significant relief and resolving symptoms in a short duration. The case study highlights the potential of Ayurvedic interventions like Kshara karma as a viable alternative to modern surgical approaches.
Reduction of Hexaconazole Residue on Apples (Pyrus malus) Using Vishaghna Dravyas: Comparative Analysis of Shirish (Albizia lebbeck) and Haridra (Curcuma longa)
ABSTRACT Background: Hexaconazole, a systemic fungicide, is extensively used in apple cultivation to manage fungal diseases. Its residue on fruits poses significant health risks, necessitating effective detoxification methods. Objective: This study evaluates the efficacy of Ayurvedic detoxifiers Shirish (Albizia lebbeck) and Haridra (Curcuma longa) in reducing Hexaconazole residue on apples. Methods: Apples were treated with Shirish Kwath, Haridra Kwath, and their combination for 5 and 15 minutes. Residue levels were quantified using the QuEChERS method followed by Gas Chromatography-Mass Spectrometry (GC-MS). Results: Both Shirish and Haridra effectively reduced Hexaconazole residue, with the combination achieving a maximum reduction of 75% after 15 minutes. Conclusion: Ayurvedic detoxifiers offer a natural and effective method for pesticide residue mitigation, enhancing food safety and supporting sustainable agricultural practices.
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Editorial: The Inaugural Issue of Journal of Ayurveda Academia (JAA)
Dear Researchers, It is with immense pleasure and a deep sense of responsibility that I welcome you to the inaugural issue of the Journal of Ayurveda Academia (JAA), January 2025 A.D. This marks the beginning of a significant journey in the dissemination of high-quality research and scholarly discussions in Ayurveda and allied sciences. The Journal of Ayurveda Academia is a bi-annual publication (June & December), available both online and in print, with a double-blinded peer-review process ensuring the highest standards of academic integrity. As an interdisciplinary journal, JAA is committed to exploring Ayurveda in conjunction with allied sciences, creating a bridge between ancient wisdom and contemporary research. Readers can access the journal at www.ayuacademia.com. Vision, Mission, and Objectives Vision: To establish the Journal of Ayurveda Academia as a premier platform for advancing evidence-based Ayurvedic research and fostering global recognition of Ayurveda as a comprehensive healthcare system. Mission: To integrate the classical wisdom of Ayurveda with modern scientific methodologies, promoting interdisciplinary research and knowledge dissemination for the benefit of humanity. Objectives: To encourage high-quality research in Ayurveda and related fields. To validate traditional Ayurvedic practices using modern scientific tools and methodologies. To foster collaboration between Ayurvedic scholars and professionals from allied sciences. To promote innovative approaches in the application of Ayurvedic principles for addressing contemporary health challenges. To create a global community of researchers, practitioners, and academicians committed to the growth and dissemination of Ayurvedic knowledge.
Discovering the Mode of Action of Mahakashaya Mentioned in Charaka Samhita Using Analytical Methods and In-Silico-Technology: A Proposal
Background: The Charaka Samhita, a cornerstone of Ayurvedic medicine, describes Mahakashayas (great categories of herbal formulations) with well-documented therapeutic applications. However, the molecular mechanisms underlying their efficacy remain largely unexplored in contemporary scientific terms. Employing analytical methods and in-silico technology offers an innovative approach to bridge this knowledge gap. Objectives: This proposal outlines a multidisciplinary strategy to investigate the mode of action of selected Mahakashayas using advanced analytical techniques and computational tools. The aim is to identify their bioactive compounds, predict molecular targets, and establish a scientific basis for their therapeutic claims. Proposed Methods: A comprehensive review of Charaka Samhita to shortlist Mahakashayas based on therapeutic relevance and feasibility for experimental investigation. Phytochemical Profiling (Employ chromatographic and spectroscopic techniques (e.g., HPLC, GC-MS, LC-MS/MS) to identify bioactive compounds in selected Mahakashayas). In-Silico Analysis: Utilize molecular docking, virtual screening, and ADMET (absorption, distribution, metabolism, excretion, and toxicity) predictions to evaluate compound interactions with potential biological targets and use network pharmacology to explore the multi-target and multi-pathway effects of the compounds. Validation Studies: Design in vitro assays (e.g., enzymatic and cell-based studies) to validate predicted molecular interactions and their biological effects. Correlate in silico findings with phytochemical and experimental data to develop a mechanistic understanding of Mahakashayas. Expected Outcomes: Identify key bioactive compounds in Mahakashayas and their molecular targets. Provide evidence for their mechanisms of action in terms of modern pharmacology. Demonstrate the utility of combining traditional knowledge with contemporary scientific tools. Significance: The study aims to establish a scientific foundation for the therapeutic efficacy of Mahakashayas, thereby facilitating their integration into evidence-based medicine. It also aims to highlight the potential of Ayurveda in drug discovery and holistic healthcare.
Mahakashaya, in-silico technology, molecular docking, network pharmacology
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Evaluation of the Clinical Efficacy of Rumex vesicarius Linn. (Chukrika) in Arochak: A Pharmacognostical and Clinical Study
Background Arochak (anorexia) is a common gastrointestinal disorder described in Ayurveda, resulting from vitiated Kapha and Vata doshas and impaired Agni (digestive fire). Traditional texts mention Chukrika (Rumex vesicarius Linn.) as Deepana (appetizer), Pachana (digestive stimulant), and Ruchya (taste enhancer), but its clinical efficacy has been inadequately studied. Objectives: To identify the correct botanical species used as Chukrika and to evaluate the clinical efficacy of Rumex vesicarius Linn. in managing Arochak. Materials and Methods Three species of Rumex—R. vesicarius, R. hastatus, and R. nepalensis—were collected from Baijnath region, Himachal Pradesh, and pharmacognostically authenticated. A single-arm clinical trial was conducted on 30 patients diagnosed with Arochak at Rajiv Gandhi Government Post Graduadate Ayurvedic College, Paprola, Himachal Pradesh. Patients received 5g of Chukrika Patra Churna twice daily with lukewarm water for 15 days. Clinical symptoms such as Ananabhilasha, Kashaya Asyata, and Picchilita were assessed using a subjective grading scale. Statistical analysis was performed using paired t-test. Results Significant improvement was observed across major symptoms:  Ananabhilasha: 80.4% relief (p<0.001)  Kashaya Asyata: 86.6% relief (p<0.001)  Picchilita: 73.07% relief (p<0.001)  Clinically, 50% of patients were cured, 33% markedly improved, and 10% moderately improved. No adverse effects were reported. Conclusion Rumex vesicarius Linn. was confirmed as the most effective Chukrika species for Arochak. The herb demonstrated significant clinical efficacy and safety, validating its traditional use and suggesting potential for broader therapeutic application in digestive disorders.